Phosphopantetheine

 Phosphopantetheine, also known as 4'-Phosphopantetheine, is an essential prosthetic group of acyl carrier protein (ACP) and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) derived from Coenzyme A.^[1] It is also present in formyltetrahydrofolate dehydrogenase.^[2]

Phosphopantetheine

Identifiers
CAS Number	2226-71-3
3D model (JSmol)	Interactive image
ChEBI	CHEBI:4222
ChemSpider	103123
DrugBank	DB03912
MeSH	phosphopantetheine
PubChem CID	115254
UNII	NM39WU8OFM
CompTox Dashboard (EPA)	DTXSID30897420
InChI InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/t9-/m0/s1  Key: JDMUPRLRUUMCTL-VIFPVBQESA-N  InChI=1/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/t9-/m0/s1 Key: JDMUPRLRUUMCTL-VIFPVBQEBX
SMILES O=C(NCCS)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)O
Properties
Chemical formula	C11H23N2O7PS
Molar mass	358.349 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

FunctionsEdit

Phosphopantetheine fulfills two demands.

• First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich thiol ester linkage.
• Second, the flexibility and length of phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites.

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.